Sweet proteins lysozyme and thaumatin are protein-type agonists for the calcium-sensing receptor.
Identifieur interne : 000008 ( Main/Exploration ); précédent : 000007; suivant : 000009Sweet proteins lysozyme and thaumatin are protein-type agonists for the calcium-sensing receptor.
Auteurs : Mizuki Yamamoto [Japon] ; Yuko Terada [Japon] ; Takayasu Motoyama [Japon] ; Tsutomu Saito [Japon] ; Keisuke Ito [Japon]Source :
- Biochemical and biophysical research communications [ 1090-2104 ] ; 2020.
Descripteurs français
- KwdFr :
- Calcium (analyse), Calcium (métabolisme), Cellules HEK293 (MeSH), Cellules cultivées (MeSH), Humains (MeSH), Hydrolyse (MeSH), Lysozyme (métabolisme), Protéines végétales (métabolisme), Relation dose-effet des médicaments (MeSH), Récepteurs-détecteurs du calcium (agonistes), Récepteurs-détecteurs du calcium (métabolisme), Électricité statique (MeSH).
- MESH :
- agonistes : Récepteurs-détecteurs du calcium.
- analyse : Calcium.
- métabolisme : Calcium, Lysozyme, Protéines végétales, Récepteurs-détecteurs du calcium.
- Cellules HEK293, Cellules cultivées, Humains, Hydrolyse, Relation dose-effet des médicaments, Électricité statique.
English descriptors
- KwdEn :
- Calcium (analysis), Calcium (metabolism), Cells, Cultured (MeSH), Dose-Response Relationship, Drug (MeSH), HEK293 Cells (MeSH), Humans (MeSH), Hydrolysis (MeSH), Muramidase (metabolism), Plant Proteins (metabolism), Receptors, Calcium-Sensing (agonists), Receptors, Calcium-Sensing (metabolism), Static Electricity (MeSH).
- MESH :
- chemical , agonists : Receptors, Calcium-Sensing.
- chemical , analysis : Calcium.
- chemical , metabolism : Calcium, Muramidase, Plant Proteins, Receptors, Calcium-Sensing.
- Cells, Cultured, Dose-Response Relationship, Drug, HEK293 Cells, Humans, Hydrolysis, Static Electricity.
Abstract
In addition to the maintenance of Ca2+ homeostasis, the calcium-sensing receptor (CaSR) is involved in many diverse physiological functions in the mammalian body. The receptor works as a kokumi taste receptor in taste buds and as a nutrient sensor in the gut, where it regulates the secretion of glycemic response and appetite-related hormones. To identify novel human CaSR (hCaSR) activators from food ingredients, we conducted a screening using a cell-based hCaSR assay. Hen egg-white lysozyme, which is a sweet protein, was found to be a novel orthosteric agonist of hCaSR with an EC50 value of 592 μM. Lysozyme hydrolysate was not able to activate hCaSR, thus suggesting that the protein structure of lysozyme is necessary for hCaSR activation. Thaumatin, which is another sweet protein, also activated hCaSR with an EC50 value of 71 μM. This is the first report that shows hCaSR activation by proteins with molecular weights exceeding 10,000 Da. These results provide a new avenue for the development of hCaSR activators, which could be applicable in food or drugs that modulate taste perception, appetite, or glucose tolerance, in addition to Ca2+ homeostasis.
DOI: 10.1016/j.bbrc.2019.10.111
PubMed: 31635806
Affiliations:
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Electronic address: s18213@u-shizuoka-ken.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526</wicri:regionArea><wicri:noRegion>422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Terada, Yuko" sort="Terada, Yuko" uniqKey="Terada Y" first="Yuko" last="Terada">Yuko Terada</name><affiliation wicri:level="1"><nlm:affiliation>Department of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. Electronic address: yukoterada@u-shizuoka-ken.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526</wicri:regionArea><wicri:noRegion>422-8526</wicri:noRegion></affiliation></author><author><name sortKey="Motoyama, Takayasu" sort="Motoyama, Takayasu" uniqKey="Motoyama T" first="Takayasu" last="Motoyama">Takayasu Motoyama</name><affiliation wicri:level="1"><nlm:affiliation>Fuji Oil Holdings Inc., Daibiru Honkan Building, 3-6-32, Nakanoshima, Kita-ku, Osaka-shi, Osaka, 530-0005, Japan. 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Electronic address: sukeito@u-shizuoka-ken.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526</wicri:regionArea><wicri:noRegion>422-8526</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biochemical and biophysical research communications</title><idno type="eISSN">1090-2104</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Calcium (analysis)</term><term>Calcium (metabolism)</term><term>Cells, Cultured (MeSH)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>HEK293 Cells (MeSH)</term><term>Humans (MeSH)</term><term>Hydrolysis (MeSH)</term><term>Muramidase (metabolism)</term><term>Plant Proteins (metabolism)</term><term>Receptors, Calcium-Sensing (agonists)</term><term>Receptors, Calcium-Sensing (metabolism)</term><term>Static Electricity (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Calcium (analyse)</term><term>Calcium (métabolisme)</term><term>Cellules HEK293 (MeSH)</term><term>Cellules cultivées (MeSH)</term><term>Humains (MeSH)</term><term>Hydrolyse (MeSH)</term><term>Lysozyme (métabolisme)</term><term>Protéines végétales (métabolisme)</term><term>Relation dose-effet des médicaments (MeSH)</term><term>Récepteurs-détecteurs du calcium (agonistes)</term><term>Récepteurs-détecteurs du calcium (métabolisme)</term><term>Électricité statique (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="agonists" xml:lang="en"><term>Receptors, Calcium-Sensing</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Calcium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcium</term><term>Muramidase</term><term>Plant Proteins</term><term>Receptors, Calcium-Sensing</term></keywords><keywords scheme="MESH" qualifier="agonistes" xml:lang="fr"><term>Récepteurs-détecteurs du calcium</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Calcium</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Calcium</term><term>Lysozyme</term><term>Protéines végétales</term><term>Récepteurs-détecteurs du calcium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cells, Cultured</term><term>Dose-Response Relationship, Drug</term><term>HEK293 Cells</term><term>Humans</term><term>Hydrolysis</term><term>Static Electricity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules HEK293</term><term>Cellules cultivées</term><term>Humains</term><term>Hydrolyse</term><term>Relation dose-effet des médicaments</term><term>Électricité statique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In addition to the maintenance of Ca<sup>2+</sup> homeostasis, the calcium-sensing receptor (CaSR) is involved in many diverse physiological functions in the mammalian body. The receptor works as a kokumi taste receptor in taste buds and as a nutrient sensor in the gut, where it regulates the secretion of glycemic response and appetite-related hormones. To identify novel human CaSR (hCaSR) activators from food ingredients, we conducted a screening using a cell-based hCaSR assay. Hen egg-white lysozyme, which is a sweet protein, was found to be a novel orthosteric agonist of hCaSR with an EC<sub>50</sub> value of 592 μM. Lysozyme hydrolysate was not able to activate hCaSR, thus suggesting that the protein structure of lysozyme is necessary for hCaSR activation. Thaumatin, which is another sweet protein, also activated hCaSR with an EC<sub>50</sub> value of 71 μM. This is the first report that shows hCaSR activation by proteins with molecular weights exceeding 10,000 Da. These results provide a new avenue for the development of hCaSR activators, which could be applicable in food or drugs that modulate taste perception, appetite, or glucose tolerance, in addition to Ca<sup>2+</sup> homeostasis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31635806</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>06</Day></DateCompleted><DateRevised><Year>2020</Year><Month>07</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2104</ISSN><JournalIssue CitedMedium="Internet"><Volume>521</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>01</Month><Day>01</Day></PubDate></JournalIssue><Title>Biochemical and biophysical research communications</Title><ISOAbbreviation>Biochem Biophys Res Commun</ISOAbbreviation></Journal><ArticleTitle>Sweet proteins lysozyme and thaumatin are protein-type agonists for the calcium-sensing receptor.</ArticleTitle><Pagination><MedlinePgn>227-231</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0006-291X(19)32013-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbrc.2019.10.111</ELocationID><Abstract><AbstractText>In addition to the maintenance of Ca<sup>2+</sup> homeostasis, the calcium-sensing receptor (CaSR) is involved in many diverse physiological functions in the mammalian body. The receptor works as a kokumi taste receptor in taste buds and as a nutrient sensor in the gut, where it regulates the secretion of glycemic response and appetite-related hormones. To identify novel human CaSR (hCaSR) activators from food ingredients, we conducted a screening using a cell-based hCaSR assay. Hen egg-white lysozyme, which is a sweet protein, was found to be a novel orthosteric agonist of hCaSR with an EC<sub>50</sub> value of 592 μM. Lysozyme hydrolysate was not able to activate hCaSR, thus suggesting that the protein structure of lysozyme is necessary for hCaSR activation. Thaumatin, which is another sweet protein, also activated hCaSR with an EC<sub>50</sub> value of 71 μM. This is the first report that shows hCaSR activation by proteins with molecular weights exceeding 10,000 Da. These results provide a new avenue for the development of hCaSR activators, which could be applicable in food or drugs that modulate taste perception, appetite, or glucose tolerance, in addition to Ca<sup>2+</sup> homeostasis.</AbstractText><CopyrightInformation>Copyright © 2019 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yamamoto</LastName><ForeName>Mizuki</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. Electronic address: s18213@u-shizuoka-ken.ac.jp.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Terada</LastName><ForeName>Yuko</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. Electronic address: yukoterada@u-shizuoka-ken.ac.jp.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Motoyama</LastName><ForeName>Takayasu</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Fuji Oil Holdings Inc., Daibiru Honkan Building, 3-6-32, Nakanoshima, Kita-ku, Osaka-shi, Osaka, 530-0005, Japan. Electronic address: motoyama.takayasu@so.fujioil.co.jp.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saito</LastName><ForeName>Tsutomu</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Fuji Oil Holdings Inc., Daibiru Honkan Building, 3-6-32, Nakanoshima, Kita-ku, Osaka-shi, Osaka, 530-0005, Japan. Electronic address: saito.tsutomu@so.fujioil.co.jp.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ito</LastName><ForeName>Keisuke</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. Electronic address: sukeito@u-shizuoka-ken.ac.jp.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>10</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biochem Biophys Res Commun</MedlineTA><NlmUniqueID>0372516</NlmUniqueID><ISSNLinking>0006-291X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044169">Receptors, Calcium-Sensing</NameOfSubstance></Chemical><Chemical><RegistryNumber>53850-34-3</RegistryNumber><NameOfSubstance UI="C003427">thaumatin protein, plant</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.1.17</RegistryNumber><NameOfSubstance UI="D009113">Muramidase</NameOfSubstance></Chemical><Chemical><RegistryNumber>SY7Q814VUP</RegistryNumber><NameOfSubstance UI="D002118">Calcium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002118" MajorTopicYN="N">Calcium</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057809" MajorTopicYN="N">HEK293 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006868" MajorTopicYN="N">Hydrolysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009113" MajorTopicYN="N">Muramidase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010940" MajorTopicYN="N">Plant Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044169" MajorTopicYN="N">Receptors, Calcium-Sensing</DescriptorName><QualifierName UI="Q000819" MajorTopicYN="Y">agonists</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055672" MajorTopicYN="N">Static Electricity</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Agonist</Keyword><Keyword MajorTopicYN="Y">Calcium-sensing receptor</Keyword><Keyword MajorTopicYN="Y">Class C GPCR</Keyword><Keyword MajorTopicYN="Y">Lysozyme</Keyword><Keyword MajorTopicYN="Y">Sweet protein</Keyword><Keyword MajorTopicYN="Y">Thaumatin</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>09</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>10</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>10</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>10</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31635806</ArticleId><ArticleId IdType="pii">S0006-291X(19)32013-3</ArticleId><ArticleId IdType="doi">10.1016/j.bbrc.2019.10.111</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Yamamoto, Mizuki" sort="Yamamoto, Mizuki" uniqKey="Yamamoto M" first="Mizuki" last="Yamamoto">Mizuki Yamamoto</name></noRegion><name sortKey="Ito, Keisuke" sort="Ito, Keisuke" uniqKey="Ito K" first="Keisuke" last="Ito">Keisuke Ito</name><name sortKey="Motoyama, Takayasu" sort="Motoyama, Takayasu" uniqKey="Motoyama T" first="Takayasu" last="Motoyama">Takayasu Motoyama</name><name sortKey="Saito, Tsutomu" sort="Saito, Tsutomu" uniqKey="Saito T" first="Tsutomu" last="Saito">Tsutomu Saito</name><name sortKey="Terada, Yuko" sort="Terada, Yuko" uniqKey="Terada Y" first="Yuko" last="Terada">Yuko Terada</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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